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- Title
Genetic variants in REC8, RNF212, and PRDM9 influence male recombination in cattle.
- Authors
Sandor, Cynthia; Li, Wanbo; Coppieters, Wouter; Druet, Tom; Charlier, Carole; Georges, Michel
- Abstract
We use >250,000 cross-over events identified in >10,000 bovine sperm cells to perform an extensive characterization of meiotic recombination in male cattle. We map Quantitative Trait Loci (QTL) influencing genome-wide recombination rate, genome-wide hotspot usage, and locus-specific recombination rate. We fine-map three QTL and present strong evidence that genetic variants in REC8 and RNF212 influence genome-wide recombination rate, while genetic variants in PRDM9 influence genome-wide hotspot usage.
- Publication
PLoS genetics, 2012, Vol 8, Issue 7, pe1002854
- ISSN
1553-7404
- Publication type
Journal Article
- DOI
10.1371/journal.pgen.1002854