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- Title
Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption.
- Authors
Cornelis, Marilyn C; Monda, Keri L; Yu, Kai; Paynter, Nina; Azzato, Elizabeth M; Bennett, Siiri N; Berndt, Sonja I; Boerwinkle, Eric; Chanock, Stephen; Chatterjee, Nilanjan; Couper, David; Curhan, Gary; Heiss, Gerardo; Hu, Frank B; Hunter, David J; Jacobs, Kevin; Jensen, Majken K; Kraft, Peter; Landi, Maria Teresa; Nettleton, Jennifer A; Purdue, Mark P; Rajaraman, Preetha; Rimm, Eric B; Rose, Lynda M; Rothman, Nathaniel; Silverman, Debra; Stolzenberg-Solomon, Rachael; Subar, Amy; Yeager, Meredith; Chasman, Daniel I; van Dam, Rob M; Caporaso, Neil E
- Abstract
We report the first genome-wide association study of habitual caffeine intake. We included 47,341 individuals of European descent based on five population-based studies within the United States. In a meta-analysis adjusted for age, sex, smoking, and eigenvectors of population variation, two loci achieved genome-wide significance: 7p21 (P = 2.4 × 10(-19)), near AHR, and 15q24 (P = 5.2 × 10(-14)), between CYP1A1 and CYP1A2. Both the AHR and CYP1A2 genes are biologically plausible candidates as CYP1A2 metabolizes caffeine and AHR regulates CYP1A2.
- Publication
PLoS genetics, 2011, Vol 7, Issue 4, pe1002033
- ISSN
1553-7404
- Publication type
Journal Article
- DOI
10.1371/journal.pgen.1002033