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- Title
Large-scale population study of human cell lines indicates that dosage compensation is virtually complete.
- Authors
Johnston, Colette M; Lovell, Frances L; Leongamornlert, Daniel A; Stranger, Barbara E; Dermitzakis, Emmanouil T; Ross, Mark T
- Abstract
X chromosome inactivation in female mammals results in dosage compensation of X-linked gene products between the sexes. In humans there is evidence that a substantial proportion of genes escape from silencing. We have carried out a large-scale analysis of gene expression in lymphoblastoid cell lines from four human populations to determine the extent to which escape from X chromosome inactivation disrupts dosage compensation. We conclude that dosage compensation is virtually complete. Overall expression from the X chromosome is only slightly higher in females and can largely be accounted for by elevated female expression of approximately 5% of X-linked genes. We suggest that the potential contribution of escape from X chromosome inactivation to phenotypic differences between the sexes is more limited than previously believed.
- Publication
PLoS genetics, 2008, Vol 4, Issue 1, pe9
- ISSN
1553-7404
- Publication type
Journal Article
- DOI
10.1371/journal.pgen.0040009