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- Title
The RNA-Binding Protein KSRP Promotes Decay of β-Catenin mRNA and Is Inactivated by PI3K-AKT Signaling.
- Authors
Gherzi, Roberto; Trabucchi, Michele; Ponassi, Marco; Ruggiero, Tina; Corte, Giorgio; Moroni, Christoph; Ching-Yi Chen; Khabar, Khalid S.; Andersen, Jens S.; Briata, Paola
- Abstract
β-catenin plays an essential role in several biological events including cell fate determination, cell proliferation, and transformation. Here we report that β-catenin is encoded by a labile transcript whose half-life is prolonged by Wnt and phosphatidylinositol 3-kinase-AKT signaling. AKT phosphorylates the mRNA decay-promoting factor KSRP at a unique serine residue, induces its association with the multifunctional protein 14-3-3, and prevents KSRP interaction with the exoribonucleolytic complex exosome. This impairs KSRP's ability to promote rapid mRNA decay. Our results uncover an unanticipated level of control of β-catenin expression pointing to KSRP as a required factor to ensure rapid degradation of β-catenin in unstimulated cells. We propose KSRP phosphorylation as a link between phosphatidylinositol 3-kinase-AKT signaling and β-catenin accumulation.
- Publication
PLoS Biology, 2007, Vol 5, Issue 1, p82
- ISSN
1544-9173
- Publication type
Academic Journal
- DOI
10.1371/journal.pbio.0050005