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- Title
Aging and Death in E. coli.
- Authors
E.J., Stewart; R., Madden; C., Paul; F., Taddci
- Abstract
The article focuses on aging and death in Escherichia coli. The researchers used automated time-lapse microscopy to follow all the cell divisions in 94 colonies, each grown from a single fluorescently labeled E. coli cell. In all, the researchers built up a lineage for 35,049 cells in terms of which pole, old or new, each cell had inherited at each division during its history. They found that the cells inheriting old poles had a reduced growth rate, decreased rate of offspring formation, and increased risk of dying compared with the cells inheriting new poles. Thus, although the cells produced when E. coli divide look identical, they are functionally asymmetric, and the old pole cell is effectively an aging parent repeatedly producing rejuvenated offspring.
- Publication
PLoS Biology, 2005, Vol 3, Issue 2, p1
- ISSN
1544-9173
- Publication type
Academic Journal
- DOI
10.1371/journal.pbio.0030045