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- Title
Endothelial membrane remodeling is obligate for anti-angiogenic radiosensitization during tumor radiosurgery.
- Authors
Truman, Jean-Philip; García-Barros, Mónica; Kaag, Matthew; Hambardzumyan, Dolores; Stancevic, Branka; Chan, Michael; Fuks, Zvi; Kolesnick, Richard; Haimovitz-Friedman, Adriana
- Abstract
While there is significant interest in combining anti-angiogenesis therapy with conventional anti-cancer treatment, clinical trials have as of yet yielded limited therapeutic gain, mainly because mechanisms of anti-angiogenic therapy remain to a large extent unknown. Currently, anti-angiogenic tumor therapy is conceptualized to either “normalize” dysfunctional tumor vasculature, or to prevent recruitment of circulating endothelial precursors into the tumor. An alternative biology, restricted to delivery of anti-angiogenics immediately prior to single dose radiotherapy (radiosurgery), is provided in the present study.
- Publication
PloS one, 2010, Vol 5, Issue 9
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/annotation/6e222ad5-b175-4a00-9d04-4d120568a897