We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Study on Hyperuricemia in HBV-Associated Glomerulonephritis.
- Authors
Yongze Zhuang; Yinghao Yu; Yingfang Huang; Xiaorong Zhong
- Abstract
Objectives: To determine the prevalence and risk factors for hyperuricemia in hepatitis B virus--associated glomerulonephritis (HBV-GN). Methods: Univariate and multivariate logistic regression analysis was applied to decide the risk factors of hyperuricemia in HBV-GN, and clinical and pathologic data were compared between HBV-GN patients with hyperuricemia and those with normal serum uric acid. Results: Among our 227 HBV-GN cases, 31.3% of the patients had hyperuricemia at the time of renal biopsy. Univariate analysis showed that the level of serum creatinine and the severity of glomerular and tubular interstitial injury were significantly related to hyperuricemia. Multivariate logistic regression analysis identified the levels of serum creatinine and tubular interstitial injury as independent factors for hyperuricemia. The incidence of hypertension and lower estimated glomerular filtration rate was significantly higher in hyperuricemic patients with HBV-GN than in normouricemic patients. There were also fewer membranous nephropathy, more proliferative sclerosing glomerulonephritis, and more tubular interstitial injury in hyperuricemic patients with HBV-GN. Conclusions: Our study results suggest that hyperuricemia is common in HBV-GN, which may facilitate the progression of HBV-GN and renal tubular interstitial injury as well as the development of hypertension.
- Publication
American Journal of Clinical Pathology, 2014, Vol 141, Issue 1, p72
- ISSN
0002-9173
- Publication type
Academic Journal
- DOI
10.1309/AJCP2H0FOVIRWMSU