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- Title
Approaches to the reversal of malnutrition, inflammation, and atherosclerosis in end-stage renal disease.
- Authors
Caglar, Kayser; Hakim, Raymond M; Ikizler, T Alp
- Abstract
Uremic malnutrition and chronic inflammation are important comorbid conditions that predict poor clinical outcome in end-stage renal disease (ESRD) patients. These conditions are also closely associated with cardiovascular disease, the major cause of death in ESRD patients. A pathophysiologic link between malnutrition, inflammation, and atherosclerosis has been proposed in this patient population. Indeed, multiple lines of evidence suggest that chronic inflammation can predispose ESRD patients to a catabolic and atherogenic state. Malnutrition can also result from chronic inflammation and can accelerate the progression of cardiovascular disease. Whereas a single common etiology has not been identified in this complex process, nutritional and anti-inflammatory interventions provide potential treatment options to counter the high mortality and morbidity in ESRD patients.
- Publication
Nutrition reviews, 2002, Vol 60, Issue 11, p378
- ISSN
0029-6643
- Publication type
Journal Article
- DOI
10.1301/00296640260385928