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- Title
Arsenic-transformed malignant prostate epithelia can convert noncontiguous normal stem cells into an oncogenic phenotype.
- Authors
Xu, Yuanyuan; Tokar, Erik J; Sun, Yang; Waalkes, Michael P
- Abstract
Cancer stem cells (CSCs) are likely critical to carcinogenesis, and, like normal stem cells (NSCs), are affected by microenvironmental factors. Malignant cells release extracellular factors, modifying tumor behavior. Inorganic arsenic, a human carcinogen, is associated with an overproduction of CSCs in various model systems of carcinogenesis.
- Publication
Environmental health perspectives, 2012, Vol 120, Issue 6, p865
- ISSN
1552-9924
- Publication type
Journal Article
- DOI
10.1289/ehp.1204987