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- Title
Bisphenol A at low nanomolar doses confers chemoresistance in estrogen receptor-alpha-positive and -negative breast cancer cells.
- Authors
Lapensee, Elizabeth W; Tuttle, Traci R; Fox, Sejal R; Ben-Jonathan, Nira
- Abstract
Resistance to chemotherapy is a major problem facing breast cancer patients, and identifying potential contributors to chemoresistance is a critical area of research. Bisphenol A (BPA) has long been suspected to promote carcinogenesis, but the high doses of BPA used in many studies generated conflicting results. In addition, the mechanism by which BPA exerts its biological actions is unclear. Although estrogen has been shown to antagonize anticancer drugs, the role of BPA in chemoresistance has not been examined.
- Publication
Environmental health perspectives, 2009, Vol 117, Issue 2, p175
- ISSN
0091-6765
- Publication type
Journal Article
- DOI
10.1289/ehp.11788