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- Title
Profiling environmental chemicals for activity in the antioxidant response element signaling pathway using a high throughput screening approach.
- Authors
Shukla, Sunita J; Huang, Ruili; Simmons, Steven O; Tice, Raymond R; Witt, Kristine L; Vanleer, Danielle; Ramabhadran, Ram; Austin, Christopher P; Xia, Menghang
- Abstract
Oxidative stress has been implicated in the pathogenesis of a variety of diseases ranging from cancer to neurodegeneration, highlighting the need to identify chemicals that can induce this effect. The antioxidant response element (ARE) signaling pathway plays an important role in the amelioration of oxidative stress. Thus, assays that detect the up-regulation of this pathway could be useful for identifying chemicals that induce oxidative stress.
- Publication
Environmental health perspectives, 2012, Vol 120, Issue 8, p1150
- ISSN
1552-9924
- Publication type
Journal Article
- DOI
10.1289/ehp.1104709