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- Title
Current status of the epidemiologic evidence linking polychlorinated biphenyls and non-hodgkin lymphoma, and the role of immune dysregulation.
- Authors
Kramer, Shira; Hikel, Stephanie Moller; Adams, Kristen; Hinds, David; Moon, Katherine
- Abstract
Although case-control studies conducted to date have largely affirmed the relationship between polychlorinated biphenyls (PCBs) and non-Hodgkin lymphoma (NHL), occupational cohort studies of PCB-exposed workers have been generally interpreted as negative, thereby raising doubts about a potential causal association. A common theme of immune dysregulation unifies many of NHL's strongest risk factors, and several authors have posited that subclinical immune dysregulation may increase NHL risk by decreasing host resistance, reducing control of cellular proliferation and differentiation, and diminishing tumor surveillance mechanisms.
- Publication
Environmental health perspectives, 2012, Vol 120, Issue 8, p1067
- ISSN
1552-9924
- Publication type
Journal Article
- DOI
10.1289/ehp.1104652