We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Direct evidence revealing structural elements essential for the high binding ability of bisphenol A to human estrogen-related receptor-gamma.
- Authors
Okada, Hiroyuki; Tokunaga, Takatoshi; Liu, Xiaohui; Takayanagi, Sayaka; Matsushima, Ayami; Shimohigashi, Yasuyuki
- Abstract
Various lines of evidence have shown that bisphenol A [BPA; HO-C6H4-C(CH3)2-C6H4-OH] acts as an endocrine disruptor when present in very low doses. We have recently demonstrated that BPA binds strongly to human estrogen-related receptor-gamma (ERR-gamma ) in a binding assay using [3H]4-hydroxytamoxifen ([3H]4-OHT). We also demonstrated that BPA inhibits the deactivation activity of 4-OHT.
- Publication
Environmental health perspectives, 2008, Vol 116, Issue 1, p32
- ISSN
0091-6765
- Publication type
Journal Article
- DOI
10.1289/ehp.10587