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- Title
Involvement of N-6 adenine-specific DNA methyltransferase 1 (N6AMT1) in arsenic biomethylation and its role in arsenic-induced toxicity.
- Authors
Ren, Xuefeng; Aleshin, Maria; Jo, William J; Dills, Russel; Kalman, David A; Vulpe, Christopher D; Smith, Martyn T; Zhang, Luoping
- Abstract
In humans, inorganic arsenic (iAs) is metabolized to methylated arsenical species in a multistep process mainly mediated by arsenic (+3 oxidation state) methyltransferase (AS3MT). Among these metabolites is monomethylarsonous acid (MMAIII), the most toxic arsenic species. A recent study in As3mt-knockout mice suggests that unidentified methyltransferases could be involved in alternative iAs methylation pathways. We found that yeast deletion mutants lacking MTQ2 were highly resistant to iAs exposure. The human ortholog of the yeast MTQ2 is N-6 adenine-specific DNA methyltransferase 1 (N6AMT1), encoding a putative methyltransferase.
- Publication
Environmental health perspectives, 2011, Vol 119, Issue 6, p771
- ISSN
1552-9924
- Publication type
Journal Article
- DOI
10.1289/ehp.1002733