We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
How should proteinuria be detected and measured?
- Authors
Lamb, Edmund J; MacKenzie, Finlay; Stevens, Paul E
- Abstract
Proteinuria is a classic sign of kidney disease and its presence carries powerful prognostic information. Although proteinuria testing is enshrined in clinical practice guidelines, there is surprising variation among such guidelines as to the definition of clinically significant proteinuria. There is also poor agreement as to whether proteinuria should be defined in terms of albumin or total protein loss, with a different approach being used to stratify diabetic and non-diabetic nephropathy. Further, the role of reagent strip devices in the detection and assessment of proteinuria is unclear. This review explores these issues in relation to recent national and international guidelines on chronic kidney disease (CKD) and epidemiological evidence linking proteinuria and clinical outcome. The authors argue that use of urinary albumin measurement as the front-line test for proteinuria detection offers the best chance of improving the sensitivity, quality and consistency of approach to the early detection and management of CKD.
- Publication
Annals of clinical biochemistry, 2009, Vol 46, Issue Pt 3, p205
- ISSN
0004-5632
- Publication type
Journal Article
- DOI
10.1258/acb.2009.009007