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- Title
A phase I trial of thermal sensitization using induced oxidative stress in the context of HIPEC.
- Authors
Harrison, Lawrence E; Tiesi, Greg; Razavi, Reza; Wang, Chia-Chi
- Abstract
Inducing oxidative stress under hyperthermic conditions significantly decreases tumor cell growth in a murine model of human colon cancer carcinomatosis. This phase I study examines the safety and pharmacokinetics of induced oxidative stress by the addition of hydrogen peroxide (H2O2) to the perfusate in patients undergoing cytoreduction and hyperthermic intraperitoneal chemotherapy (HIPEC) for advanced abdominal-only malignancies.
- Publication
Annals of surgical oncology, 2013, Vol 20, Issue 6, p1843
- ISSN
1534-4681
- Publication type
Journal Article
- DOI
10.1245/s10434-013-2874-0