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- Title
Expression analysis of aldehyde dehydrogenase 1A1 (ALDH1A1) in colon and rectal cancer in association with prognosis and response to chemotherapy.
- Authors
Kahlert, Christoph; Gaitzsch, Eva; Steinert, Gunnar; Mogler, Carolin; Herpel, Esther; Hoffmeister, Michael; Jansen, Lina; Benner, Axel; Brenner, Hermann; Chang-Claude, Jenny; Rahbari, Nuh; Schmidt, Thomas; Klupp, Fee; Grabe, Niels; Lahrmann, Bernd; Koch, Moritz; Halama, Niels; Büchler, Markus; Weitz, Juergen
- Abstract
Aldehyde dehydrogenase 1A1 (ALDH1A1) has been described as a cancer stem cell marker and as a regulator of cellular chemoresistance. Therefore, ALDH1A1 has been suggested as potential biomarker to stratify patients into different risk categories for a "personalized" therapy approach. We have investigated the prognostic role of ALDH1A1 in primary colorectal cancer and its value in predicting response to chemotherapy in metastatic colorectal cancer.
- Publication
Annals of surgical oncology, 2012, Vol 19, Issue 13, p4193
- ISSN
1534-4681
- Publication type
Journal Article
- DOI
10.1245/s10434-012-2518-9