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Title: Empagliflozin and Renal Sodium-Hydrogen Exchange in Healthy Subjects.
Authors: Biancalana, Edoardo; Rossi, Chiara; Raggi, Francesco; Distaso, Mariarosaria; Tricò, Domenico; Baldi, Simona; Ferrannini, Ele; Solini, Anna
Abstract: Sodium glucose co-transporter-2 inhibitors exert clinically relevant cardiorenal protection. Among several mechanisms, inhibition of sodium-hydrogen exchanger-3 (NHE3) in proximal renal tubules has been proposed in rodents. Demonstration of this mechanism with the associated electrolyte and metabolic changes in humans is lacking.
Publication: The Journal of clinical endocrinology and metabolism, 2023, Vol 108, Issue 8, pe567
ISSN: 1945-7197
Publication type: Journal Article
DOI: 10.1210/clinem/dgad088

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Empagliflozin and Renal Sodium-Hydrogen Exchange in Healthy Subjects.