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- Title
Thymidylate synthase genotype-directed neoadjuvant chemoradiation for patients with rectal adenocarcinoma.
- Authors
Tan, Benjamin R; Thomas, Fabienne; Myerson, Robert J; Zehnbauer, Barbara; Trinkaus, Kathryn; Malyapa, Robert S; Mutch, Matthew G; Abbey, Elliot E; Alyasiry, Amer; Fleshman, James W; McLeod, Howard L
- Abstract
Downstaging (DS) of rectal cancers is achieved in approximately 45% of patients with neoadjuvant fluorouracil (FU) -based chemoradiotherapy (CRT). Polymorphisms in the thymidylate synthase gene (TYMS) had previously defined two risk groups associated with disparate tumor DS rates (60% v 22%). We conducted a prospective single-institution phase II study using TYMS genotyping to direct neoadjuvant CRT for patients with rectal cancer.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011, Vol 29, Issue 7, p875
- ISSN
1527-7755
- Publication type
Journal Article
- DOI
10.1200/JCO.2010.32.3212