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- Title
Progression from high-grade prostatic intraepithelial neoplasia to cancer: a randomized trial of combination vitamin-E, soy, and selenium.
- Authors
Fleshner, Neil E; Kapusta, Linda; Donnelly, Bryan; Tanguay, Simon; Chin, Joseph; Hersey, Karen; Farley, Anne; Jansz, Ken; Siemens, D Robert; Trpkov, Kiril; Lacombe, Louis; Gleave, Martin; Tu, Dongsheng; Parulekar, Wendy R
- Abstract
High-grade prostatic intraepithelial neoplasia (HGPIN) is a putative precursor of invasive prostate cancer (PCa). Preclinical evidence suggests vitamin E, selenium, and soy protein may prevent progression of HGPIN to PCa. This hypothesis was tested in a randomized phase III double-blind study of daily soy (40 g), vitamin E (800 U), and selenium (200 μg) versus placebo.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011, Vol 29, Issue 17, p2386
- ISSN
1527-7755
- Publication type
Journal Article
- DOI
10.1200/JCO.2010.32.0994