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- Title
WT1 mutation and 11P15 loss of heterozygosity predict relapse in very low-risk wilms tumors treated with surgery alone: a children's oncology group study.
- Authors
Perlman, Elizabeth J; Grundy, Paul E; Anderson, James R; Jennings, Lawrence J; Green, Daniel M; Dome, Jeffrey S; Shamberger, Robert C; Ruteshouser, E Cristy; Huff, Vicki
- Abstract
Children's Oncology Group defines very low-risk Wilms tumors (VLRWT) as stage I favorable histology Wilms tumors weighing less than 550 g in children younger than 24 months of age. VLRWTs may be treated with nephrectomy alone. However, 10% to 15% of VLRWTs relapse without chemotherapy. Previous studies suggest that VLRWTs with low WT1 expression and/or 11p15 loss of heterozygosity (LOH) may have increased risk of relapse. The current study validates these findings within prospectively identified children with VLRWT who did not receive adjuvant chemotherapy.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011, Vol 29, Issue 6, p698
- ISSN
1527-7755
- Publication type
Journal Article
- DOI
10.1200/JCO.2010.31.5192