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- Title
Phase III trial of prophylactic cranial irradiation compared with observation in patients with locally advanced non-small-cell lung cancer: neurocognitive and quality-of-life analysis.
- Authors
Sun, Alexander; Bae, Kyounghwa; Gore, Elizabeth M; Movsas, Benjamin; Wong, Stuart J; Meyers, Christina A; Bonner, James A; Schild, Steven E; Gaspar, Laurie E; Bogart, Jeffery A; Werner-Wasik, Maria; Choy, Hak
- Abstract
There are scant data regarding the effects of prophylactic cranial irradiation (PCI) on neurocognitive function (NCF) and quality of life (QOL). Radiation Therapy Oncology Group trial 0214 showed no overall survival (OS) benefit for PCI in stage III non-small-cell lung cancer (NSCLC) at 1 year. However, there was a significant decrease in brain metastases (BM). This analysis focuses on the impact of PCI on NCF and QOL.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011, Vol 29, Issue 3, p279
- ISSN
1527-7755
- Publication type
Journal Article
- DOI
10.1200/JCO.2010.29.6053