We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Immunologic escape after prolonged progression-free survival with epidermal growth factor receptor variant III peptide vaccination in patients with newly diagnosed glioblastoma.
- Authors
Sampson, John H; Heimberger, Amy B; Archer, Gary E; Aldape, Kenneth D; Friedman, Allan H; Friedman, Henry S; Gilbert, Mark R; Herndon, James E, 2nd; McLendon, Roger E; Mitchell, Duane A; Reardon, David A; Sawaya, Raymond; Schmittling, Robert J; Shi, Weiming; Vredenburgh, James J; Bigner, Darell D
- Abstract
Immunologic targeting of tumor-specific gene mutations may allow precise eradication of neoplastic cells without toxicity. Epidermal growth factor receptor variant III (EGFRvIII) is a constitutively activated and immunogenic mutation not expressed in normal tissues but widely expressed in glioblastoma multiforme (GBM) and other neoplasms.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010, Vol 28, Issue 31, p4722
- ISSN
1527-7755
- Publication type
Journal Article
- DOI
10.1200/JCO.2010.28.6963