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- Title
Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome.
- Authors
Cho, Yoon-Jae; Tsherniak, Aviad; Tamayo, Pablo; Santagata, Sandro; Ligon, Azra; Greulich, Heidi; Berhoukim, Rameen; Amani, Vladimir; Goumnerova, Liliana; Eberhart, Charles G; Lau, Ching C; Olson, James M; Gilbertson, Richard J; Gajjar, Amar; Delattre, Olivier; Kool, Marcel; Ligon, Keith; Meyerson, Matthew; Mesirov, Jill P; Pomeroy, Scott L
- Abstract
Medulloblastomas are heterogeneous tumors that collectively represent the most common malignant brain tumor in children. To understand the molecular characteristics underlying their heterogeneity and to identify whether such characteristics represent risk factors for patients with this disease, we performed an integrated genomic analysis of a large series of primary tumors.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011, Vol 29, Issue 11, p1424
- ISSN
1527-7755
- Publication type
Journal Article
- DOI
10.1200/JCO.2010.28.5148