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- Title
Oxaliplatin-mediated increase in spleen size as a biomarker for the development of hepatic sinusoidal injury.
- Authors
Overman, Michael J; Maru, Dipen M; Charnsangavej, Chusilp; Loyer, Evelyn M; Wang, Huamin; Pathak, Priyanka; Eng, Cathy; Hoff, Paulo M; Vauthey, Jean-Nicolas; Wolff, Robert A; Kopetz, Scott
- Abstract
Oxaliplatin-based chemotherapy can cause hepatic sinusoidal injury, with resultant sinusoidal damage and portal hypertension. We sought to explore the relationship between oxaliplatin induced hepatic sinusoidal injury, increases in spleen size, and the subsequent development of thrombocytopenia.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010, Vol 28, Issue 15, p2549
- ISSN
1527-7755
- Publication type
Journal Article
- DOI
10.1200/JCO.2009.27.5701