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- Title
Phase II evaluation of paclitaxel and carboplatin in the treatment of carcinosarcoma of the uterus: a Gynecologic Oncology Group study.
- Authors
Powell, Matthew A; Filiaci, Virginia L; Rose, Peter G; Mannel, Robert S; Hanjani, Parviz; Degeest, Koen; Miller, Brigitte E; Susumu, Nobuyuki; Ueland, Frederick R
- Abstract
Platinum and taxane compounds have demonstrated activity in uterine carcinosarcoma (malignant mixed Mullerian tumor). Ifosfamide plus paclitaxel is the regimen with established superiority based on a randomized phase III trial conducted through the Gynecologic Oncology Group. However, the toxicity, multiday schedule, and limited activity of this regimen support further development of novel regimens. Our primary objective was to estimate the antitumor activity and toxicity of paclitaxel plus carboplatin in patients with uterine carcinosarcomas.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010, Vol 28, Issue 16, p2727
- ISSN
1527-7755
- Publication type
Journal Article
- DOI
10.1200/JCO.2009.26.8326