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- Title
Independent adjudication of symptomatic heart failure with the use of doxorubicin and cyclophosphamide followed by trastuzumab adjuvant therapy: a combined review of cardiac data from the National Surgical Adjuvant breast and Bowel Project B-31 and the North Central Cancer Treatment Group N9831 clinical trials.
- Authors
Russell, Stuart D; Blackwell, Kimberly L; Lawrence, Julia; Pippen, John E, Jr; Roe, Matthew T; Wood, Freda; Paton, Virginia; Holmgren, Eric; Mahaffey, Kenneth W
- Abstract
An independent Adjuvant Cardiac Review and Evaluation Committee (ACREC) systematically reviewed cases of symptomatic heart failure events to uniformly define the cardiac event rate across two large trials (National Surgical Adjuvant Breast and Bowel Project [NSABP] B-31 and North Central Cancer Treatment Group [NCCTG] N9831) that assessed the addition of trastuzumab to standard adjuvant chemotherapy.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010, Vol 28, Issue 21, p3416
- ISSN
1527-7755
- Publication type
Journal Article
- DOI
10.1200/JCO.2009.23.6950