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- Title
Timed sequential treatment with cyclophosphamide, doxorubicin, and an allogeneic granulocyte-macrophage colony-stimulating factor-secreting breast tumor vaccine: a chemotherapy dose-ranging factorial study of safety and immune activation.
- Authors
Emens, Leisha A; Asquith, Justin M; Leatherman, James M; Kobrin, Barry J; Petrik, Silvia; Laiko, Marina; Levi, Joy; Daphtary, Maithili M; Biedrzycki, Barbara; Wolff, Antonio C; Stearns, Vered; Disis, Mary L; Ye, Xiaobu; Piantadosi, Steven; Fetting, John H; Davidson, Nancy E; Jaffee, Elizabeth M
- Abstract
Granulocyte-macrophage colony-stimulating factor (GM-CSF) -secreting tumor vaccines have demonstrated bioactivity but may be limited by disease burdens and immune tolerance. We tested the hypothesis that cyclophosphamide (CY) and doxorubicin (DOX) can enhance vaccine-induced immunity in patients with breast cancer.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009, Vol 27, Issue 35, p5911
- ISSN
1527-7755
- Publication type
Journal Article
- DOI
10.1200/JCO.2009.23.3494