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- Title
Association between disease-free survival and overall survival when survival is prolonged after recurrence in patients receiving cytotoxic adjuvant therapy for colon cancer: simulations based on the 20,800 patient ACCENT data set.
- Authors
de Gramont, Aimery; Hubbard, Joleen; Shi, Qian; O'Connell, Michael J; Buyse, Marc; Benedetti, Jacqueline; Bot, Brian; O'Callaghan, Chris; Yothers, Greg; Goldberg, Richard M; Blanke, Charles D; Benson, Al; Deng, Qiqi; Alberts, Steven R; Andre, Thierry; Wolmark, Norman; Grothey, Axel; Sargent, Daniel
- Abstract
We previously validated disease-free survival (DFS) as a surrogate for overall survival (OS) in fluorouracil-based adjuvant colon cancer clinical trials. New therapies have extended survival after recurrence from 1 to approximately 2 years. We examined the possible impact of this improvement on the DFS/OS association.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010, Vol 28, Issue 3, p460
- ISSN
1527-7755
- Publication type
Journal Article
- DOI
10.1200/JCO.2009.23.1407