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- Title
Phase I/II trial of AEG35156 X-linked inhibitor of apoptosis protein antisense oligonucleotide combined with idarubicin and cytarabine in patients with relapsed or primary refractory acute myeloid leukemia.
- Authors
Schimmer, Aaron D; Estey, Elihu H; Borthakur, Gautam; Carter, Bing Z; Schiller, Gary J; Tallman, Martin S; Altman, Jessica K; Karp, Judith E; Kassis, Jeannine; Hedley, David W; Brandwein, Joseph; Xu, Wei; Mak, Duncan H; LaCasse, Eric; Jacob, Christine; Morris, Stephen J; Jolivet, Jacques; Andreeff, Michael
- Abstract
X-linked inhibitor of apoptosis protein (XIAP) is an inhibitor of caspases 3 and 9 which are overexpressed in acute myeloid leukemia (AML) and may contribute to chemoresistance. We report on a phase I/II trial of the XIAP antisense oligonucleotide AEG35156 in combination with reinduction chemotherapy.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009, Vol 27, Issue 28, p4741
- ISSN
1527-7755
- Publication type
Journal Article
- DOI
10.1200/JCO.2009.21.8172