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- Title
Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer.
- Authors
Jiralerspong, Sao; Palla, Shana L; Giordano, Sharon H; Meric-Bernstam, Funda; Liedtke, Cornelia; Barnett, Chad M; Hsu, Limin; Hung, Mien-Chie; Hortobagyi, Gabriel N; Gonzalez-Angulo, Ana M
- Abstract
Population studies have suggested that metformin use in diabetic patients decreases cancer incidence and mortality. Metformin inhibits the growth of cancer cells in vitro and tumors in vivo. However, there is little clinical data to support this. Our purpose was to determine whether metformin use was associated with a change in pathologic complete response (pCR) rates in diabetic patients with breast cancer receiving neoadjuvant chemotherapy.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009, Vol 27, Issue 20, p3297
- ISSN
1527-7755
- Publication type
Journal Article
- DOI
10.1200/JCO.2009.19.6410