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- Title
Clinical implications of the colorectal cancer risk associated with MUTYH mutation.
- Authors
Lubbe, Steven J; Di Bernardo, Maria Chiara; Chandler, Ian P; Houlston, Richard S
- Abstract
Biallelic mutations in the base excision DNA repair gene MUTYH predispose to colorectal cancer (CRC). Evidence that monoallelic mutations also confer an elevated CRC risk is controversial. Precise quantification of the CRC risk and the phenotype associated with MUTYH mutations is relevant to the counseling, surveillance, and clinical management of at-risk individuals.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009, Vol 27, Issue 24, p3975
- ISSN
1527-7755
- Publication type
Journal Article
- DOI
10.1200/JCO.2008.21.6853