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- Title
Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects.
- Authors
Treviño, Lisa R; Shimasaki, Noriko; Yang, Wenjian; Panetta, John C; Cheng, Cheng; Pei, Deqing; Chan, Diana; Sparreboom, Alex; Giacomini, Kathleen M; Pui, Ching-Hon; Evans, William E; Relling, Mary V
- Abstract
Methotrexate plasma concentration is related to its clinical effects. Our aim was to identify the genetic basis of interindividual variability in methotrexate pharmacokinetics in children with newly diagnosed acute lymphoblastic leukemia (ALL).
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009, Vol 27, Issue 35, p5972
- ISSN
1527-7755
- Publication type
Journal Article
- DOI
10.1200/JCO.2008.20.4156