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- Title
Colorectal cancer risk perception on the basis of genetic test results in individuals at risk for Lynch syndrome.
- Authors
Grover, Shilpa; Stoffel, Elena M; Mercado, Rowena C; Ford, Beth M; Kohlman, Wendy K; Shannon, Kristen M; Conrad, Peggy G; Blanco, Amie M; Terdiman, Jonathan P; Gruber, Stephen B; Chung, Daniel C; Syngal, Sapna
- Abstract
Lynch syndrome is associated with inherited germline mutations in mismatch repair (MMR) genes. Genetic testing in high-risk individuals may yield indeterminate results if no mutation is found or if a mutation of unclear pathogenic significance is observed. There are limited data regarding how well patients with Lynch syndrome understand the clinical implications of genetic test results. This study examines colorectal cancer (CRC) risk perception in individuals tested for MMR mutations and identifies the factors associated with an appropriate interpretation of their cancer risk.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009, Vol 27, Issue 24, p3981
- ISSN
1527-7755
- Publication type
Journal Article
- DOI
10.1200/JCO.2008.18.6940