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- Title
Microsatellite instability predicts improved response to adjuvant therapy with irinotecan, fluorouracil, and leucovorin in stage III colon cancer: Cancer and Leukemia Group B Protocol 89803.
- Authors
Bertagnolli, Monica M; Niedzwiecki, Donna; Compton, Carolyn C; Hahn, Hejin P; Hall, Margaret; Damas, Beatrice; Jewell, Scott D; Mayer, Robert J; Goldberg, Richard M; Saltz, Leonard B; Warren, Robert S; Redston, Mark
- Abstract
Colon cancers exhibiting DNA mismatch repair (MMR) defects demonstrate distinct clinical and pathologic features, including better prognosis and reduced response to fluorouracil (FU) -based chemotherapy. This prospective study investigated adjuvant chemotherapy containing FU and irinotecan in patients with MMR deficient (MMR-D) colon cancers.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009, Vol 27, Issue 11, p1814
- ISSN
1527-7755
- Publication type
Journal Article
- DOI
10.1200/JCO.2008.18.2071