We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Insulin, the insulin-like growth factor axis, and mortality in patients with nonmetastatic colorectal cancer.
- Authors
Wolpin, Brian M; Meyerhardt, Jeffrey A; Chan, Andrew T; Ng, Kimmie; Chan, Jennifer A; Wu, Kana; Pollak, Michael N; Giovannucci, Edward L; Fuchs, Charles S
- Abstract
Obesity, sedentary lifestyle, and Western dietary pattern have been linked to increased risk of cancer recurrence and mortality among patients with surgically resected colorectal cancer. Excess energy balance leads to increased circulating insulin and depressed levels of circulating insulin-like growth factor binding protein (IGFBP) -1, which promote cancer cell growth in preclinical models.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009, Vol 27, Issue 2, p176
- ISSN
1527-7755
- Publication type
Journal Article
- DOI
10.1200/JCO.2008.17.9945