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- Title
Genomic strategy for targeting therapy in castration-resistant prostate cancer.
- Authors
Mendiratta, Prateek; Mostaghel, Elahe; Guinney, Justin; Tewari, Alok K; Porrello, Alessandro; Barry, William T; Nelson, Peter S; Febbo, Phillip G
- Abstract
Despite treatments which lower circulating androgens, advanced prostate cancers often maintain androgen receptor (AR) signaling. The variable response to secondary hormonal manipulations in men with castrate-resistant prostate cancer (CRPC) creates a compelling need for strategies to individualize therapy based on the molecular features of each patient's tumor.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009, Vol 27, Issue 12, p2022
- ISSN
1527-7755
- Publication type
Journal Article
- DOI
10.1200/JCO.2008.17.2882