We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Randomized trial of denosumab in patients receiving adjuvant aromatase inhibitors for nonmetastatic breast cancer.
- Authors
Ellis, Georgiana K; Bone, Henry G; Chlebowski, Rowan; Paul, Devchand; Spadafora, Silvana; Smith, Judy; Fan, Michelle; Jun, Susie
- Abstract
Adjuvant aromatase inhibitor therapy is well established in postmenopausal women with hormone receptor-positive breast cancer, but such therapy is complicated by accelerated bone loss and increased fracture risk. We investigated the ability of denosumab, a fully human monoclonal antibody against receptor activator of nuclear factor-kappaB ligand, to protect against aromatase inhibitor-induced bone loss.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008, Vol 26, Issue 30, p4875
- ISSN
1527-7755
- Publication type
Journal Article
- DOI
10.1200/JCO.2008.16.3832