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- Title
Primary and secondary kinase genotypes correlate with the biological and clinical activity of sunitinib in imatinib-resistant gastrointestinal stromal tumor.
- Authors
Heinrich, Michael C; Maki, Robert G; Corless, Christopher L; Antonescu, Cristina R; Harlow, Amy; Griffith, Diana; Town, Ajia; McKinley, Arin; Ou, Wen-Bin; Fletcher, Jonathan A; Fletcher, Christopher D M; Huang, Xin; Cohen, Darrel P; Baum, Charles M; Demetri, George D
- Abstract
Most gastrointestinal stromal tumors (GISTs) harbor mutant KIT or platelet-derived growth factor receptor alpha (PDGFRA) kinases, which are imatinib targets. Sunitinib, which targets KIT, PDGFRs, and several other kinases, has demonstrated efficacy in patients with GIST after they experience imatinib failure. We evaluated the impact of primary and secondary kinase genotype on sunitinib activity.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008, Vol 26, Issue 33, p5352
- ISSN
1527-7755
- Publication type
Journal Article
- DOI
10.1200/JCO.2007.15.7461