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- Title
Phase I trial of the human immunodeficiency virus protease inhibitor nelfinavir and chemoradiation for locally advanced pancreatic cancer.
- Authors
Brunner, Thomas B; Geiger, Matthias; Grabenbauer, Gerhard G; Lang-Welzenbach, Marga; Mantoni, Tine S; Cavallaro, Alexander; Sauer, Rolf; Hohenberger, Werner; McKenna, W Gillies
- Abstract
Preclinically, HIV protease inhibitors radiosensitize tumors with activated PI3-kinase/Akt pathway. We determined the toxicity of nelfinavir chemoradiotherapy in borderline resectable and unresectable pancreatic cancer.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008, Vol 26, Issue 16, p2699
- ISSN
1527-7755
- Publication type
Journal Article
- DOI
10.1200/JCO.2007.15.2355