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- Title
Gene expression profiling to identify the histogenetic origin of metastatic adenocarcinomas of unknown primary.
- Authors
Horlings, Hugo M; van Laar, Ryan K; Kerst, Jan-Martijn; Helgason, Helgi H; Wesseling, Jelle; van der Hoeven, Jacobus J M; Warmoes, Marc O; Floore, Arno; Witteveen, Anke; Lahti-Domenici, Jaana; Glas, Annuska M; Van't Veer, Laura J; de Jong, Daphne
- Abstract
Patients with adenocarcinoma of unknown primary origin (ACUP) constitute approximately 4% of all malignancies. For effective treatment of these patients, it is considered optimal to identify the primary tumor origins. Currently, the success rate of the diagnostic work-up is only 20% to 30%. Our goal was to evaluate the contribution of gene expression profiling for routine clinical practice in patients with ACUP.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008, Vol 26, Issue 27, p4435
- ISSN
1527-7755
- Publication type
Journal Article
- DOI
10.1200/JCO.2007.14.6969