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- Title
DNA damage and repair capacity in patients with lung cancer: prediction of multiple primary tumors.
- Authors
Orlow, Irene; Park, Bernard J; Mujumdar, Urvi; Patel, Himali; Siu-Lau, Puiki; Clas, Brian A; Downey, Robert; Flores, Raja; Bains, Manjit; Rizk, Nabil; Dominguez, Gemma; Jani, Jen; Berwick, Marianne; Begg, Colin B; Kris, Mark G; Rusch, Valerie W
- Abstract
Patients who survive one occurrence of non-small-cell lung cancer (NSCLC) are at higher risk of a second malignancy. Capacity to repair damaged DNA may modulate individual susceptibility to develop lung cancer. Therefore, we evaluated constitutive and induced DNA damage, and repair capacity, in patients with multiple NSCLCs (cases) and compared the results to those obtained in patients with a single NSCLC (controls).
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008, Vol 26, Issue 21, p3560
- ISSN
1527-7755
- Publication type
Journal Article
- DOI
10.1200/JCO.2007.13.2654