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- Title
Prognostic and predictive importance of p53 and RAS for adjuvant chemotherapy in non small-cell lung cancer.
- Authors
Tsao, Ming-Sound; Aviel-Ronen, Sarit; Ding, Keyue; Lau, Davina; Liu, Ni; Sakurada, Akira; Whitehead, Marlo; Zhu, Chang-Qi; Livingston, Robert; Johnson, David H; Rigas, James; Seymour, Lesley; Winton, Timothy; Shepherd, Frances A
- Abstract
p53 and RAS are multifunctional proteins that are critical to cell cycle regulation, apoptosis, cell survival, gene transcription, response to stress, and DNA repair. We have evaluated the prognostic and predictive value of p53 gene/protein aberrations using tumor samples from JBR.10, a North American phase III intergroup trial that randomly assigned 482 patients with completely resected stage IB and II non-small-cell lung cancer (NSCLC) to receive four cycles of adjuvant cisplatin plus vinorelbine or observation alone.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007, Vol 25, Issue 33, p5240
- ISSN
1527-7755
- Publication type
Journal Article
- DOI
10.1200/JCO.2007.12.6953