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- Title
Patients with curative resection of cT3-4 rectal cancer after preoperative radiotherapy or radiochemotherapy: does anybody benefit from adjuvant fluorouracil-based chemotherapy? A trial of the European Organisation for Research and Treatment of Cancer Radiation Oncology Group.
- Authors
Collette, Laurence; Bosset, Jean-Francois; den Dulk, Marcel; Nguyen, France; Mineur, Laurent; Maingon, Philippe; Radosevic-Jelic, Ljiljana; Piérart, Marianne; Calais, Gilles; European Organisation for Research and Treatment of Cancer Radiation Oncology Group
- Abstract
European Organisation for Research and Treatment of Cancer (EORTC) trial 22921 compared adjuvant fluorouracil-based chemotherapy (CT) to no adjuvant treatment in a 2 x 2 factorial trial with randomization for preoperative (chemo)radiotherapy in patients with resectable T3-4 rectal cancer. The results showed no significant impact of adjuvant CT on progression-free or overall survival, although a difference seemed to emerge at approximately, respectively, 2 and 5 years after the start of preoperative treatment. We further explored the data with the aim of refining our understanding of the long-term results.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007, Vol 25, Issue 28, p4379
- ISSN
1527-7755
- Publication type
Journal Article
- DOI
10.1200/JCO.2007.11.9685