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- Title
Progression-free survival is a surrogate for survival in advanced colorectal cancer.
- Authors
Buyse, Marc; Burzykowski, Tomasz; Carroll, Kevin; Michiels, Stefan; Sargent, Daniel J; Miller, Langdon L; Elfring, Gary L; Pignon, Jean-Pierre; Piedbois, Pascal
- Abstract
The traditional end point for assessing efficacy of first-line chemotherapies for advanced cancer is overall survival (OS), but this end point requires prolonged follow-up and is potentially confounded by the effects of second-line therapies. We investigated whether progression-free survival (PFS) could be considered a valid surrogate for OS in advanced colorectal cancer.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007, Vol 25, Issue 33, p5218
- ISSN
1527-7755
- Publication type
Journal Article
- DOI
10.1200/JCO.2007.11.8836