We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Nuclear factor-kB tumor expression predicts response and survival in irinotecan-refractory metastatic colorectal cancer treated with cetuximab-irinotecan therapy.
- Authors
Scartozzi, Mario; Bearzi, Italo; Pierantoni, Chiara; Mandolesi, Alessandra; Loupakis, Fotios; Zaniboni, Alberto; Catalano, Vincenzo; Quadri, Antonello; Zorzi, Fausto; Berardi, Rossana; Biscotti, Tommasina; Labianca, Roberto; Falcone, Alfredo; Cascinu, Stefano
- Abstract
NF-kB expression has been shown to be responsible for resistance to antineoplastic agents and it also plays a part in the activation of the epidermal growth factor receptor downstream signaling pathway in colorectal tumors. The aim of our analysis was to investigate a correlation between NF-kB expression, response rate, time to progression, and survival in advanced colorectal cancer patients receiving cetuximab and irinotecan.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007, Vol 25, Issue 25, p3930
- ISSN
1527-7755
- Publication type
Journal Article
- DOI
10.1200/JCO.2007.11.5022