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- Title
Irinotecan fluorouracil plus leucovorin is not superior to fluorouracil plus leucovorin alone as adjuvant treatment for stage III colon cancer: results of CALGB 89803.
- Authors
Saltz, Leonard B; Niedzwiecki, Donna; Hollis, Donna; Goldberg, Richard M; Hantel, Alexander; Thomas, James P; Fields, Anthony L A; Mayer, Robert J
- Abstract
Randomized studies have shown that irinotecan (CPT-11) extends survival in metastatic colorectal cancer patients when administered in second-line and when added to fluorouracil (FU) plus leucovorin (LV) in first-line therapy of metastatic colorectal cancer. When this study was initiated, FU plus LV was standard adjuvant treatment for stage III colon cancer. We evaluated the efficacy and safety of weekly bolus CPT-11 plus FU plus LV in the treatment of patients with completely resected stage III colon cancer.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007, Vol 25, Issue 23, p3456
- ISSN
1527-7755
- Publication type
Journal Article
- DOI
10.1200/JCO.2007.11.2144