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- Title
Predicting treatment response of malignant gliomas to bevacizumab and irinotecan by imaging proliferation with [18F] fluorothymidine positron emission tomography: a pilot study.
- Authors
Chen, Wei; Delaloye, Sibylle; Silverman, Daniel H S; Geist, Cheri; Czernin, Johannes; Sayre, James; Satyamurthy, Nagichettiar; Pope, Whitney; Lai, Albert; Phelps, Michael E; Cloughesy, Timothy
- Abstract
Evaluation of treatment effects in malignant brain tumors is challenging because of the lack of reliable response predictors of tumor response. This study examines the predictive value of positron emission tomography (PET) using [18F] fluorothymidine (FLT), an imaging biomarker of cell proliferation, in patients with recurrent malignant gliomas treated with bevacizumab in combination with irinotecan.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007, Vol 25, Issue 30, p4714
- ISSN
1527-7755
- Publication type
Journal Article
- DOI
10.1200/JCO.2006.10.5825