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- Title
End points for colon cancer adjuvant trials: observations and recommendations based on individual patient data from 20,898 patients enrolled onto 18 randomized trials from the ACCENT Group.
- Authors
Sargent, Daniel J; Patiyil, Smitha; Yothers, Greg; Haller, Daniel G; Gray, Richard; Benedetti, Jacqueline; Buyse, Marc; Labianca, Roberto; Seitz, Jean Francois; O'Callaghan, Christopher J; Francini, Guido; Grothey, Axel; O'Connell, Michael; Catalano, Paul J; Kerr, David; Green, Erin; Wieand, Harry S; Goldberg, Richard M; de Gramont, Aimery; ACCENT Group
- Abstract
The traditional end point for colon adjuvant clinical trials is overall survival (OS). We previously validated disease-free survival (DFS) after 3-year follow-up as an excellent predictor of 5-year OS results. Here we explore shorter term DFS and OS end points, as well as stage dependency.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007, Vol 25, Issue 29, p4569
- ISSN
1527-7755
- Publication type
Journal Article
- DOI
10.1200/JCO.2006.10.4323