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- Title
Role of genetic and nongenetic factors for fluorouracil treatment-related severe toxicity: a prospective clinical trial by the German 5-FU Toxicity Study Group.
- Authors
Schwab, Matthias; Zanger, Ulrich M; Marx, Claudia; Schaeffeler, Elke; Klein, Kathrin; Dippon, Jürgen; Kerb, Reinhold; Blievernicht, Julia; Fischer, Joachim; Hofmann, Ute; Bokemeyer, Carsten; Eichelbaum, Michel; German 5-FU Toxicity Study Group
- Abstract
To assess the predictive value of polymorphisms in dihydropyrimidine dehydrogenase (DPYD ), thymidylate synthase (TYMS ), and methylene tetrahydrofolate reductase (MTHFR ) and of nongenetic factors for severe leukopenia, diarrhea, and mucositis related to fluorouracil (FU) treatment.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008, Vol 26, Issue 13, p2131
- ISSN
1527-7755
- Publication type
Journal Article
- DOI
10.1200/JCO.2006.10.4182